Title: Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum
Authors: Otshudi, A Longanga ×
Apers, Sandra
Pieters, L
Claeys, M
Pannecouque, Christophe
De Clercq, Erik
Van Zeebroeck, A
Lauwers, S
Frédérich, M
Foriers, A #
Issue Date: Oct-2005
Series Title: Journal of ethnopharmacology vol:102 issue:1 pages:89-94
Abstract: Methanol and water extracts of the root of Epinetrum villosum (Exell) Troupin (Menispermaceae) were found to exhibit antimicrobial and antiplasmodial activities. Investigation of the active methanol fraction led to the isolation of four bisbenzylisoquinoline alkaloids, i.e., cycleanine, cycleanine N-oxide, isochondodendrine and cocsoline. Structures were established by spectroscopic methods. Cocsoline displayed antibacterial and antifungal activities (MIC values of 1000-15.62 and 31.25 microg/ml, respectively). Isochondodendrine was found to have the most potent antiplasmodial activity (IC50 = 0.10 microg/ml), whereas the IC50 on HCT-116 human colon carcinoma cells was 17.5 microg/ml (selectivity index 175). Cycleanine acted against HIV-2 (EC50=1.83 microg/ml) but was at least 10-fold less active against HIV-1. Cycleanine N-oxide showed no activity towards all tested microorganisms.
ISSN: 0378-8741
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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