Title: Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides
Authors: Barral, Karine ×
Courcambeck, Jérôme
Pèpe, Gérard
Balzarini, Jan
Neyt, Johan
De Clercq, Erik
Camplo, Michel #
Issue Date: Jan-2005
Publisher: ACS Publications
Series Title: Journal of Medicinal Chemistry vol:48 issue:2 pages:450-456
Abstract: Starting from commercially available (rac)-3-cyclohexene-1-carboxylic acid, a series of purine and pyrimidine cis-substituted cyclohexenyl and cyclohexanyl nucleosides were synthesized through a key Mitsunobu reaction. Antiviral evaluations were performed on HIV, coxsackie B3, and herpes viruses (HSV-1, HSV-2, VZV, HCMV). Three compounds showed moderate activity against HSV-1 and coxsackie viruses. Specific computer modeling studies were performed on HSV-1 thymidine kinase in order to understand the enzyme activation of an analogue showing moderate antiviral activity.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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