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Title: Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle
Authors: Van Coillie, E ×
Van Aelst, I
Wuyts, Anja
Vercauteren, R
Devos, R
Peeters, Christiane
Van Damme, Jozef
Opdenakker, Ghislain #
Issue Date: Oct-2001
Series Title: American Journal of Pathology vol:159 issue:4 pages:1405-14
Abstract: Chemokine production by tumors is a well-known phenomenon, but its role in tumor biology remains debatable. Although intratumoral injection of granulocyte chemotactic protein-2 (GCP-2) had no effect on tumor parameters, needle-free stable expression of the chemokine resulted in enhanced tumor growth. It is shown here that tumors that express a potent form of GCP-2 induce a strong influx and activation of tumor-associated neutrophils. The production of GCP-2 leads to intratumoral expression of gelatinase B and advantage for tumor growth by increased angiogenesis. These results are in line with the countercurrent principle of chemokine action and support the notion that paraneoplastic expression of ELR-positive CXC chemokines has to be blocked rather than stimulated in cancer therapy.
ISSN: 0002-9440
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Academic Center for General Practice
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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