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Title: Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation
Authors: Hallenborg, P
Feddersen, S
Francoz, S
Murano, I
Sundekilde, U
Petersen, R K
Akimov, V
Olson, M V
Lozano, G
Cinti, S
Gjertsen, B T
Madsen, L
Marine, Chris
Blagoev, B
Kristiansen, K # ×
Issue Date: Aug-2012
Publisher: E. Arnold
Series Title: Cell Death and Differentiation vol:19 issue:8 pages:1381-1389
Article number: 10.1038/cdd.2012.15
Abstract: The role of the E3 ubiquitin ligase murine double minute 2 (Mdm2) in regulating the stability of the p53 tumor suppressor is well documented. By contrast, relatively little is known about p53-independent activities of Mdm2 and the role of Mdm2 in cellular differentiation. Here we report a novel role for Mdm2 in the initiation of adipocyte differentiation that is independent of its ability to regulate p53. We show that Mdm2 is required for cAMP-mediated induction of CCAAT/enhancer-binding protein δ (C/EBPδ) expression by facilitating recruitment of the cAMP regulatory element-binding protein (CREB) coactivator, CREB-regulated transcription coactivator (Crtc2)/TORC2, to the c/ebpδ promoter. Our findings reveal an unexpected role for Mdm2 in the regulation of CREB-dependent transactivation during the initiation of adipogenesis. As Mdm2 is able to promote adipogenesis in the myoblast cell line C2C12, it is conceivable that Mdm2 acts as a switch in cell fate determination.
URI: 
ISSN: 1350-9047
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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