Title: A critical review why assessment of steroid hormone receptors in breast cancer should be quantitative
Authors: Brouckaert, O ×
Paridaens, Robert
Floris, Guiseppe
Rakha, E
Osborne, K
Neven, Patrick #
Issue Date: Jan-2013
Publisher: Kluwer Academic Publishers
Series Title: Annals of Oncology vol:24 issue:1 pages:47-53
Abstract: Steroid receptors have been around in the field of breast cancer for decades now. Still, controversy remains on how best to report steroid receptors. In this review, we will convince the reader why benefits outweigh pitfalls, when reporting steroid receptors in a quantitative rather than qualitative way. Summarizing decades of research in this field, we will explore the evidence why quantitative reporting is superior in all settings (neoadjuvant, adjuvant and metastatic settings). Furthermore, we will also summarize different staining methods, definitions and pitfalls that have shown to be important points of discussion in earlier debates. Although the molecular unraveling of breast cancer in the past decade has revolutionized the way we think about breast cancer, we should not easily abandon the classical pathological variables such as steroid receptors in favor of molecular tools.
ISSN: 0923-7534
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Laboratory of Experimental Oncology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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