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Title: Anti-HIV properties of cationic fullerene derivatives
Authors: Marchesan, Silvia ×
Da Ros, Tatiana
Spalluto, Giampiero
Balzarini, Jan
Prato, Maurizio #
Issue Date: Aug-2005
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:15 issue:15 pages:3615-3618
Abstract: A series of regioisomeric bis-fulleropyrrolidines bearing two ammonium groups have been synthesized and their activities against HIV-1 and HIV-2 have been evaluated. Two trans isomers have been endowed with interesting antiviral properties, confirming the importance of the relative positions of the substituent on the C(60) cage. In addition, reduced amphiphilicity of molecules to other compounds previously reported decreases their cytotoxicity in CEM cell cultures. None of the compounds showed any inhibitory activity against a variety of DNA and RNA viruses other than HIV.
URI: 
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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