Title: Identification of residual metabolic-active areas within NSCLC tumours using a pre-radiotherapy FDG-PET-CT scan: A prospective validation
Authors: Aerts, Hugo J. W. L ×
Bussink, Johan
Oyen, Wim J. G
van Elmpt, Wouter
Folgering, Annemieke M
Emans, Daisy
Velders, Marije
Lambin, Philippe
De Ruysscher, Dirk #
Issue Date: Jan-2012
Publisher: Elsevier
Series Title: Lung Cancer vol:75 issue:1 pages:73-76
Abstract: It was recently described that high FDG-uptake areas pre-radiotherapy largely correspond with residual metabolic-active areas post-radiotherapy. Here, an independent prospective validation of these results was performed using an overlap-fraction (OF) calculation of various FOG-uptake based thresholds. Data from twelve patients treated at Radboud University Nijmegen Medical Center with lung cancer were analyzed. All patients underwent two FDG-PET-CT scans, one pre-radiotherapy (pre-RT) and one approximately three months after treatment (post-RT). Of the twelve analyzed patients, eight patients showed residual FDG uptake on the post-RT scan and were included for analysis. One of these patients had a residue that was not clearly distinguishable from the surrounding tissue due to FDG avid inflammation. Therefore, seven patients remained for further analysis. The mean volume of the residual metabolic-active areas post-RT was 14.6 +/- 10.0% (mean +/- SD) of the mean volume of the gross tumour volume (GTV) pre-RT. The residual metabolic-active areas largely corresponded with the pre-RT GTV (OF = 93.7 +/- 7.2%). The pre-RT-scan threshold delineations of 34%, 40% and 50% of the SUVmax had a large OF with the residual region, 86.9 +/- 8.3%, 77.4 +/- 8.1% and 67.9 +/- 6.8%, respectively. In this independent dataset, we confirmed that the location of residual FDG-uptake areas after radiotherapy corresponds with the high FDG-uptake areas pre-radiotherapy. Therefore, a pre-radiotherapy FDG-PET-CT scan can potentially be used for radiotherapy dose redistribution. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0169-5002
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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