Individualized radical radiotherapy of non-small-cell lung cancer based on normal tissue dose constraints: A feasibility study
van Baardwijk, Angela × Bosmans, Geert Boersma, Liesbeth Wanders, Stofferinus Dekker, Andre Dingemans, Anne Marie C Bootsma, Gerben Geraedts, Wiel Pitz, Cordula Simons, Jean Lambin, Philippe De Ruysscher, Dirk #
International Journal of Radiation Oncology, Biology, Physics vol:71 issue:5 pages:1394-1401
Purpose: Local recurrence is a major problem after (chemo-) radiation for non-small-cell lung cancer. We hypothesized that for each individual patient, the highest therapeutic ratio could be achieved by increasing total tumor dose (TTD) to the limits of normal tissues, delivered within 5 weeks. We report first results of a prospective feasibility trial.