PET imaging of hypoxia using [F-18]HX4: a phase I trial
van Loon, Judith × Janssen, Marco H. M Ollers, Michel Aerts, Hugo J. W. L Dubois, Ludwig Hochstenbag, Monique Dingemans, Anne-Marie C Lalisang, Roy Brans, Boudewijn Windhorst, Bert van Dongen, Guus A Kolb, Hartmuth Zhang, James De Ruysscher, Dirk Lambin, Philippe #
European Journal of Nuclear Medicine and Molecular Imaging vol:37 issue:9 pages:1663-1668
Noninvasive PET imaging of tumour hypoxia could help in the selection of those patients who could benefit from chemotherapy or radiation with specific antihypoxic treatments such as bioreductive drugs or hypoxic radiosensitizers. In this phase I trial, we aimed to determine the toxicity of [F-18]HX4, a member of the 2-nitroimidazole family, at different dose levels. The secondary aim was to analyse image quality related to the HX4 dose and the timing of imaging.