Author:

Keywords:

treatment planning studies, in silico, radiotherapy, multicentric, clinical trial, quality assurance, public repositories, data pooling, cell lung-cancer, complication probability-models, health-care enterprise, silico clinical-trial, pet, feasibility, standards, pathology, tumor, Science & Technology, Life Sciences & Biomedicine, Oncology, Radiology, Nuclear Medicine & Medical Imaging, Treatment planning studies, In silico, Radiotherapy, Multicentric, Clinical trial, Quality assurance, Public repositories, Data pooling, CELL LUNG-CANCER, COMPLICATION PROBABILITY-MODELS, HEALTH-CARE ENTERPRISE, SILICO CLINICAL-TRIAL, PET, FEASIBILITY, STANDARDS, PATHOLOGY, TUMOR, Clinical Trials as Topic, Humans, Multicenter Studies as Topic, Quality Assurance, Health Care, Radiotherapy Planning, Computer-Assisted, 0299 Other Physical Sciences, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3202 Clinical sciences, 3211 Oncology and carcinogenesis, 5105 Medical and biological physics

Abstract:

This report introduces a framework for comparing radiotherapy treatment planning in multicentric in silico clinical trials. Quality assurance, data incompatibility, transfer and storage issues, and uniform analysis of results are discussed. The solutions that are given provide a useful guide for the set-up of future multicentric planning studies or public repositories of high quality data. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 567-571