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Title: The maximum uptake of F-18-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-lot and GLUT-1 in non-small cell lung cancer
Authors: van Baardwijk, Angela ×
Dooms, Christophe
van Suylen, Robert Jan
Verbeken, Erik
Hochstenbag, Monique
Dehing-Oberije, Cary
Rupa, Dennis
Pastorekova, Silvia
Stroobants, Sigrid
Buell, Ulrich
Lambin, Philippe
Vansteenkiste, Johan
De Ruysscher, Dirk #
Issue Date: Jun-2007
Publisher: Pergamon
Series Title: European Journal of Cancer vol:43 issue:9 pages:1392-1398
Abstract: The purpose of this study was to investigate the relation between the standardised uptake value (SUV) on F-18-fluoro-2-deoxy-glucose-positron emission tomography scan and hypoxia related markers (HIF-lo( and CAIX), a proliferation-related marker (Ki-67) and glucose transporters (GLUT-1 and GLUT-3) in non-small cell lung cancer (NSCLC). One hundred and two patients, scheduled for complete resection, received a PET scan in Leuven or Maastricht/Aachen. The maximal SUV (SUVmax) was correlated with survival and immunohistochemical staining patterns. The actuarial survival was worse for patients showing a high SUVmax the best discriminative value being 8.0 (Leuven, p = 0.032) and 11.0 (Maastricht, p = 0.007). T umours with a high SUVmax expressed in a higher proportion HIF-1 alpha (63.1% versus 37.9%, p = 0.024) and GLUT-1 (82.9% versus 62.5%, p = 0.025), than tumours with a low SUVmax No significant difference was found in the expression of CAIX, Ki-67 and GLUT-3. This study supports preclinical data that hypoxia is associated with a higher uptake of FDG. (C) 2007 Elsevier Ltd. All rights reserved.
URI: 
ISSN: 0959-8049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Laboratory of Experimental Radiotherapy
Pneumology
Department of Oncology - miscellaneous
× corresponding author
# (joint) last author

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