Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients
Dehing-Oberije, Cary × De Ruysscher, Dirk Petit, Steven Van Meerbeeck, Jan Vandecasteele, Katrien De Neve, Wilfried Dingemans, Anne Marie C El Naqa, Issam Deasy, Joseph Bradley, Jeff Huang, Ellen Lambin, Philippe #
Elsevier Science Publishers
Radiotherapy and Oncology vol:97 issue:3 pages:455-461
Introduction: Acute dysphagia is a distressing dose-limiting toxicity occurring frequently during concurrent chemo-radiation or high-dose radiotherapy for lung cancer. It can lead to treatment interruptions and thus jeopardize survival. Although a number of predictive factors have been identified, it is still not clear how these could offer assistance for treatment decision making in daily clinical practice. Therefore, we have developed and validated a nomogram to predict this side-effect. In addition, clinical usefulness was assessed by comparing model predictions to physicians' predictions.