Selective nodal irradiation on basis of (18)fdg-pet scans in limited-disease small-cell lung cancer: a prospective study

van Loon, Judith; De Ruysscher, Dirk; Wanders, Rinus; Boersma, Liesbeth; Simons, Jean; Oellers, Michel; Dingemans, Anne-Marie C; Hochstenbag, Monique; Bootsma, Gerben; Geraedts, Wiel; Pitz, Cordula; Teule, Jaap; Rhami, Ali; Thimister, Willy; Snoep, Gabriel; Dehing-Oberije, Cary; Lambin, Philippe

doi:10.1016/j.ijrobp.2009.04.075

Selective nodal irradiation on basis of (18)fdg-pet scans in limited-disease small-cell lung cancer: a prospective study

Author:

van Loon, Judith

De Ruysscher, Dirk ; Wanders, Rinus ; Boersma, Liesbeth ; Simons, Jean ; Oellers, Michel ; Dingemans, Anne-Marie C ; Hochstenbag, Monique ; Bootsma, Gerben ; Geraedts, Wiel ; Pitz, Cordula ; Teule, Jaap ; Rhami, Ali ; Thimister, Willy ; Snoep, Gabriel ; Dehing-Oberije, Cary ; Lambin, Philippe

Keywords:

selective nodal irradiation, small cell lung cancer, positron emission tomography, pet, combined modality treatment, elective nodal irradiation, positron-emission-tomography, involved-field radiotherapy, fdg-pet scan, phase-ii, concurrent chemotherapy, dose-escalation, radiation, stage, ct, etoposide, Science & Technology, Life Sciences & Biomedicine, Oncology, Radiology, Nuclear Medicine & Medical Imaging, Selective nodal irradiation, PET, POSITRON-EMISSION-TOMOGRAPHY, INVOLVED-FIELD RADIOTHERAPY, FDG-PET SCAN, PHASE-II, CONCURRENT CHEMOTHERAPY, DOSE-ESCALATION, RADIATION, STAGE, CT, ETOPOSIDE, Antineoplastic Combined Chemotherapy Protocols, Carboplatin, Combined Modality Therapy, Etoposide, Female, Fluorodeoxyglucose F18, Humans, Lung Neoplasms, Lymphatic Irradiation, Male, Mediastinum, Middle Aged, Positron-Emission Tomography, Prospective Studies, Radiopharmaceuticals, Radiotherapy Dosage, Radiotherapy, Conformal, Small Cell Lung Carcinoma, Survival Analysis, Tomography, X-Ray Computed, 0299 Other Physical Sciences, 1103 Clinical Sciences, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3211 Oncology and carcinogenesis, 3407 Theoretical and computational chemistry, 5105 Medical and biological physics

Abstract:

Purpose: To evaluate the results of selective nodal irradiation on basis of F-18-deoxyglucose positron emission tomography (PET) scans in patients with limited-disease small-cell lung cancer (LD-SCLC) on isolated nodal failure.