Title: Guards of the great wall: bacterial lysozyme inhibitors
Authors: Callewaert, Lien ×
Van Herreweghe, Joris M
Vanderkelen, Lise
Leysen, Seppe
Voet, Arnout
Michiels, Chris #
Issue Date: Oct-2012
Publisher: Elsevier Trends Journals
Series Title: Trends in microbiology vol:20 issue:10 pages:501-510
Abstract: Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly specific bacterial proteinaceous lysozyme inhibitors against the three major animal lysozyme families have been discovered in bacteria, and these may represent a bacterial answer to animal lysozymes. Here, we will review their properties and phylogenetic distribution, present their structure and molecular interaction mechanism with lysozyme, and discuss their possible biological functions and potential applications.
ISSN: 0966-842X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Food and Microbial Technology
× corresponding author
# (joint) last author

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