Title: Are the 2-isomers of the drug rimantadine active anti-influenza A agents?
Authors: Zoidis, Grigoris ×
Kolocouris, Nicolas
Foscolos, George B
Kolocouris, Antonios
Fytas, George
Karayannis, P
Padalko, Elizaveta
Neyts, Johan
De Clercq, Erik #
Issue Date: May-2003
Series Title: Antiviral chemistry & chemotherapy vol:14 issue:3 pages:153-64
Abstract: There is a lack of information in the medical chemistry literature concerning the anti-influenza A activity of the drug rimantadine's 2-isomer (2-rimantadine). We now present results showing that, although 2-adamantanamine (2-amantadine) 3 is only moderately active, some 2-rimantadine analogues are effective anti-influenza A virus agents in vitro. The 2-rimantadine analogues and their spirocyclobutane and spirocyclopentane congeners were synthesized through interesting routes. The 2-rimantadine analogues were 2-4 times more potent than rimantadine 2 against influenza virus A H2N2 strain; their spirocyclobutane congeners proved equally active to rimantadine 2. Two compounds exhibited a similar activity and one of the compounds was was fourfold more potent than rimantadine 2 against H3N2 strain.
ISSN: 0956-3202
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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