Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma
Korf, Hannelie Pynaert, Gwenda Tournoy, Kurt Boonefaes, Tom Van Oosterhout, Antoon Ginneberge, Daisy Haegeman, Anuschka Verschoor, Jan A De Baetselier, Patrick Grooten, Johan # ×
American Lung Association
American Journal of Respiratory and Critical Care Medicine vol:174 issue:2 pages:152-60
Mycolic acid (MA) constitutes a major and distinguishing cell wall biolipid from Mycobacterium tuberculosis. MA interferes with the lipid homeostasis of alveolar macrophages, inducing differentiation into foamy macrophages exhibiting increased proinflammatory function.