Title: Analysis of complex HIV-1 intersubtype recombinants using a Bayesian scanning method
Authors: Paraskevis, D ×
Deforche, Koen
Abecasis, A
Camacho, R
Vandamme, Anne-Mieke #
Issue Date: Apr-2005
Series Title: Infection, Genetics and Evolution vol:5 issue:3 pages:219-24
Abstract: The increased complexity of HIV-1 genetic heterogeneity raises the issue for reliable classification and analysis of these sequences. Until now, bootscanning analysis has been the main method used for the analysis of potential HIV-1 intersubtype recombinants. We show evidence that in some cases of complex recombinants, where three or more segments with discordant phylogenetic signal may exist in protease (PR) and partial reverse transcriptase (RT) region, Bayesian scanning provides a clearer picture than bootscanning plots about the boundaries of potential recombination. Thus, a recently developed Bayesian scanning tool can facilitate the analysis and classification of HIV-1 mosaic sequences.
ISSN: 1567-1348
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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