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Title: Treatment of classical Kaposi's sarcoma with intralesional injections of cidofovir: report of a case
Authors: Simonart, T ×
Noel, J C
De Dobbeleer, G
Parent, D
Van Vooren, J P
De Clercq, Erik
Snoeck, Robert #
Issue Date: Jul-1998
Series Title: Journal of medical virology vol:55 issue:3 pages:215-8
Abstract: The effect of intralesional injections of cidofovir, a nucleotide analog with potent in vitro activity against human herpesvirus 8 (HHV-8), was studied in vivo in an HIV-negative patient with classical Kaposi's sarcoma (KS). After five weekly injections of the drug, no clinical, histological, immunohistological, or virological changes could be detected in comparison with saline-injected lesions. These findings suggest that, once the KS tumor has developed, active viral replication is no longer involved in the pathogenesis of the disease. Alternative hypotheses are that HHV-8 replication in blood-borne cells may foster growth of spindle cells in the skin, or that blocking HHV-8 may not affect existing lesions but may prevent new lesions from developing.
URI: 
ISSN: 0146-6615
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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