Title: Molecular testing of multiple HIV-1 transmissions in a criminal case
Authors: Lemey, Philippe ×
Van Dooren, Sonia
Van Laethem, Kristel
Schrooten, Yoeri
Derdelinckx, Inge
Goubau, Patrick
Brun-Vézinet, Francoise
Vaira, Dolores
Vandamme, Anne-Mieke #
Issue Date: Oct-2005
Publisher: Gower Academic Journals
Series Title: AIDS vol:19 issue:15 pages:1649-1658
Abstract: OBJECTIVE: To test the a priori hypothesis of HIV-1 transmission from one suspect to six recipients in a criminal case. METHODS: Partial pol and/or env sequences were obtained for at least two samples of the suspect and the victims. Appropriate local controls were sampled based on epidemiological and subtype criteria. Phylogenetic testing was performed using different reconstruction methods. RESULTS: Phylogenetic analyses consistently inferred a monophyletic cluster for the suspect and victim samples in both genome regions. This was highly supported by parametric and non-parametric bootstrapping techniques. Moreover, the controls most closely related to the suspect-victim cluster had a similar geographical origin to the suspect. CONCLUSIONS: Taking into account the limitations on the conclusions that can be drawn from molecular investigations we could infer that our molecular data is consistent with a scenario of multiple HIV transmission between suspect and victims.
ISSN: 0269-9370
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Laboratory for Clinical Infectious and Inflammatory Disorders
× corresponding author
# (joint) last author

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