Title: Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine
Authors: Gerona-Navarro, Guillermo ×
Pérez de Vega, M Jesús
García-López, M Teresa
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik
González-Muñiz, Rosario #
Issue Date: May-2004
Series Title: Bioorganic & medicinal chemistry letters vol:14 issue:9 pages:2253-6
Abstract: Different Phe-derived 1-acyl-beta-lactams, analogous to a series of 2-azetidinones acting as HCMV serine protease inhibitors, were synthesized. Some of these compounds were modest inhibitors of the HCMV replication. Interestingly, removal of the carbonyl group of the beta-lactam ring, most likely acting as the serine trap, resulted in an azetidine derivative with anti-HCMV activity comparable to that of the reference compound ganciclovir.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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