Title: Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives
Authors: Narang, Rakesh ×
Narasimhan, Balasubramanian
Sharma, Sunil
Sriram, Dharmarajan
Yogeeswari, Perumal
De Clercq, Erik
Pannecouque, Christophe
Balzarini, Jan #
Issue Date: Aug-2012
Publisher: Birkhäuser Boston
Series Title: Medicinal Chemistry Research vol:21 issue:8 pages:1557-1576
Abstract: A series of nicotinic acid benzylidene hydrazide derivatives (1-18) was synthesized and tested in vitro for biological evaluations. The antimycobacterial activity results indicated that the presence of electron-withdrawing halogen groups at para position of the phenyl ring improved their activity. The results of antiviral evaluation depicted that none of the synthesized derivatives inhibited the replication of viruses at subtoxic concentration. Further, the antimicrobial screening results indicated that compounds having OCH3 and NO2 substituents were the most active ones. QSAR investigations revealed that multi-target QSAR models were effective in describing the antimicrobial activity.
ISSN: 1054-2523
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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