Title: The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Authors: Benilova, Iryna
Karran, Eric
De Strooper, Bart # ×
Issue Date: Mar-2012
Publisher: Nature America Inc.
Series Title: Nature Neuroscience vol:15 issue:3 pages:349-57
Article number: 10.1038/nn.3028
Abstract: The 'toxic Aβ oligomer' hypothesis has attracted considerable attention among Alzheimer's disease researchers as a way of resolving the lack of correlation between deposited amyloid-β (Aβ) in amyloid plaques-in terms of both amount and location-and cognitive impairment or neurodegeneration. However, the lack of a common, agreed-upon experimental description of the toxic Aβ oligomer makes interpretation and direct comparison of data between different research groups impossible. Here we critically review the evidence supporting toxic Aβ oligomers as drivers of neurodegeneration and make some suggestions that might facilitate progress in this complex field.
ISSN: 1097-6256
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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