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Title: Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency
Authors: Vos, Melissa
Esposito, Giovanni
Edirisinghe, Janaka N
Vilain, Sven
Haddad, Dominik
Slabbaert, Jan
Van Meensel, Stefanie
Schaap, Onno
De Strooper, Bart
Meganathan, R
Morais, Vanessa
Verstreken, Patrik # ×
Issue Date: Jun-2012
Publisher: American Association for the Advancement of Science
Series Title: Science vol:336 issue:6086 pages:1306-10
Abstract: Human UBIAD1 localizes to mitochondria and converts vitamin K(1) to vitamin K(2). Vitamin K(2) is best known as a cofactor in blood coagulation, but in bacteria it is a membrane-bound electron carrier. Whether vitamin K(2) exerts a similar carrier function in eukaryotic cells is unknown. We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function. We found that vitamin K(2) was necessary and sufficient to transfer electrons in Drosophila mitochondria. Heix mutants showed severe mitochondrial defects that were rescued by vitamin K(2), and, similar to ubiquinone, vitamin K(2) transferred electrons in Drosophila mitochondria, resulting in more efficient adenosine triphosphate (ATP) production. Thus, mitochondrial dysfunction was rescued by vitamin K(2) that serves as a mitochondrial electron carrier, helping to maintain normal ATP production.
URI: 
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for the Research of Neurodegenerative Diseases
Laboratory of Neuronal Communication
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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