Title: Different epidemic potentials of the HIV-1B and C subtypes
Authors: Salemi, Marco ×
de Oliveira, Tulio
Soares, Marcelo A
Pybus, Oliver
Dumans, Ana T
Vandamme, Anne-Mieke
Tanuri, Amilcar
Cassol, Sharon
Fitch, Walter M #
Issue Date: May-2005
Publisher: Springer Verlag
Series Title: Journal of Molecular Evolution vol:60 issue:5 pages:598-605
Abstract: HIV, the cause of AIDS in humans, is characterized by great genetic heterogeneity. In particular, HIV-1 group M subtypes are responsible for most of the infections worldwide. We investigate the demographic history of HIV-1B and HIV-1C subtypes in South Africa and Brazil using both a parametric and a nonparametric approach based on coalescent theory. Our results show that although both subtypes are spreading exponentially in Brazil, the HIV-1C growth rate is about twice that of Brazilian HIV-1B or South African HIV-1C, providing evidence, for the first time, of a different epidemic potential between two HIV-1 subtypes. The present study not only may have important consequences for devising future vaccination and therapeutic strategies, but also offers additional evidence that skyline plots are indeed a simple and powerful tool for monitoring and predicting the behavior of viral epidemics.
ISSN: 0022-2844
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
× corresponding author
# (joint) last author

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