Title: Aryl furano pyrimidines: the most potent and selective anti-VZV agents reported to date
Authors: McGuigan, Christopher ×
Balzarini, Jan #
Issue Date: Sep-2006
Publisher: Elsevier/North-Holland
Series Title: Antiviral Research vol:71 issue:2-3 pages:149-153
Abstract: Bicyclic aryl furano pyrimidines represent the most potent anti-VZV agents reported to date. Lead compounds have EC50 values in vitro as low as 0.1 nM and selectivity index values exceeding one million. They have an absolute requirement for VZV thymidine kinase (TK) and most likely act as their phosphate forms. Some structural modification, such as aryl substitution, is tolerated, while little sugar modification is acceptable. We herein summarise their biological profiles and structure activity relationships as discovered to date.
ISSN: 0166-3542
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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