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Title: Frontal Eye Field microstimulation induces task-dependent gamma oscillations in the Lateral Intraparietal area
Authors: Premereur, Elsie
Vanduffel, Wim
Roelfsema, P.
Janssen, Peter # ×
Issue Date: Sep-2012
Publisher: The Society
Series Title: Journal of Neurophysiology vol:108 issue:5 pages:1392-1402
Abstract: Macaque frontal eye fields (FEF) and the lateral Intraparietal area (LIP) are high-level oculomotor control centers that have been implicated in the allocation of spatial attention. Electrical microstimulation of
macaque FEF elicits functional magnetic resonance imaging
(fMRI) activations in area LIP, but no study has yet investigated the effect of FEF microstimulation on LIP at the single-cell or local field potential (LFP) level. We recorded spiking and LFP activity in area LIP during weak, subthreshold microstimulation of the FEF in a delayed-saccade task. FEF microstimulation caused a highly
time- and frequency-specific, task-dependent increase in gamma power in retinotopically corresponding sites in LIP: FEF microstimulation produced a significant increase in LIP gamma power when a saccade target appeared and remained present in the LIP receptive field (RF), whereas less specific increases in alpha power were evoked by FEF microstimulation for saccades directed away from the RF. Stimulating FEF with weak currents had no effect on LIP spike rates or on the gamma power during memory saccades or
passive fixation. These results provide the first evidence for task-dependent modulations of LFPs in LIP caused by top-down stimulation of FEF. Since the allocation and disengagement of spatial attention in visual cortex have been associated with increases in gamma and alpha power, respectively, the effects of FEF microstimulation
on LIP are consistent with the known effects of spatial
attention.
ISSN: 0022-3077
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Neurophysiology
× corresponding author
# (joint) last author

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