Title: Synthesis and fluorescent properties of the tricyclic analogues of acyclovir linked with nitrogen heterocyclic units
Authors: Goslinski, Tomasz
Januszczyk, Piotr
Wenska, Grazyna
Golankiewicz, Bozenna
De Clercq, Erik
Balzarini, Jan #
Issue Date: Jan-2005
Host Document: Nucleosides, nucleotides & nucleic acids vol:24 pages:571-5
Conference: XVIth International Round Table on "Nucleosides, Nucleotides and Nucleic Acids" location:Minneapolis, Minnesota, USA date:12-16 September 2004
Abstract: Tricyclic (T, 3,9-dihydro-9-oxo-SH-imidazo[g2-c]purine) analogues of acyclovir (ACV, 1), substituted in the 6 position with pyrid-4-yl, 4-(pyrid-4'-yl)Ph, 4-(pyrimidin-5-yl)Ph and 4-(thiazol-2'-yl)Ph units were synthesized. For the synthesis of the heteroarylphenyl derivatives, a convenient general route was developed, ie., Suzuki cross-coupling between protected 6-(4-dihydroxyborylphenyl) TACV and easily available bromoheterocycles. Fluorescent properties of newly synthesized TACV aoalogues strongly depend on the nature of a solvent. This sensitivity of fluorescence makes the compounds promising probes of H-bonding in the environment.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
# (joint) last author

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