Title: Synthesis and in vitro cytotoxic and antiviral activities of 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and derivatives
Authors: Tronchet, Jean M J ×
Chalard, Frederic
Rivara-Minten, Elisabeth
Seman, Michel
De Clercq, Erik
Balzarini, Jan
Dilda, Pierre #
Issue Date: Jan-2002
Series Title: Nucleosides, nucleotides & nucleic acids vol:21 issue:3 pages:191-206
Abstract: All 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and their 3'-O-TBDMS derivatives have been prepared and their configuration established. Some of these compounds are endowed with a cytotoxic or cytostatic activity in cell culture. The single most important factor affecting the cytotoxicity of these compounds is the presence on the molecule of a soft (electrofugal) halogen atom.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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