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Title: Synthesis and biological evaluation of isonucleosides derived from methyl 3,5-anhydro-2-O-(2-fluorobenzyl)-D-xylofuranosides
Authors: Wirsching, Jörn ×
Schulze, Oliver
Voss, Jürgen
Giesler, Anja
Kopf, Jürgen
Adiwidjaja, Gunadi
Balzarini, Jan
De Clercq, Erik #
Issue Date: Jan-2002
Series Title: Nucleosides, nucleotides & nucleic acids vol:21 issue:3 pages:257-74
Abstract: New isonucleosides [methyl 5-(1-pyrimidinyl)furanosides] are prepared by nucleophilic opening of the oxetane ring of methyl 3,5-anhydro-2-O-(2-fluorobenzyl)-D-xylofuranoside with silylated pyrimidine bases in the presence of trimethylsilyl triflate. Structures, configurations and conformations were determined by NMR techniques and several X-ray diffraction analyses, seven of the isonucleosides were tested for cytotoxicity and activity against HIV, HSV and several other viruses.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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