Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer
van der Horst, Paul H × Wang, Yongyi Vandenput, Ingrid Kühne, Liesbeth C Ewing, Patricia C van Ijcken, Wilfred F J van der Zee, Marten Amant, Frédéric Burger, Curt W Blok, Leen J #
Public Library of Sciene
PLoS One vol:7 issue:1 pages:e30840-e30840
Every year approximately 74,000 women die of endometrial cancer, mainly due to recurrent or metastatic disease. The presence of tumor infiltrating lymphocytes (TILs) as well as progesterone receptor (PR) positivity has been correlated with improved prognosis. This study describes two mechanisms by which progesterone inhibits metastatic spread of endometrial cancer: by stimulating T-cell infiltration and by inhibiting epithelial-to-mesenchymal cell transition (EMT).