Title: Aryloxy phosphoramidate triesters as pro-tides
Authors: Cahard, Dominique ×
McGuigan, Christopher
Balzarini, Jan #
Issue Date: May-2004
Series Title: Mini reviews in medicinal chemistry vol:4 issue:4 pages:371-81
Abstract: We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular delivery of charged bio-active antiviral nucleoside monophosphates. The review covers the discovery of such aryl phosphoramidates, their mechanism of action and structure-activity relationships. The application of this strategy to a range of antiviral nucleosides is highlighted.
ISSN: 1389-5575
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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