"Lock-in"-cycloSal-pronucleotides - a new generation of chemical Trojan Horses?
Meier, Chris × Ruppel, Manuel F H Vukadinovic, Dalibor Balzarini, Jan #
Mini reviews in medicinal chemistry vol:4 issue:4 pages:383-94
The cycloSal-concept is one example of a successful nucleotide delivering system (pronucleotide). For several nucleoside analogues, the cycloSal-approach improved the antiviral potency and the applicability of the nucleosides could be broadened. Here, a conceptional extension of the original design of the cycloSal-system will be discussed.