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Title: Sarcopenia and bone mineral density in European men
Authors: Gielen, Evelien
Verschueren, Sabine
O'Neill, Terence
Pye, Stephen
Adams, Judith
Ward, Kate
Wu, Frederick
Szulc, Pawel
Laurent, Michaƫl
Claessens, Frank
Vanderschueren, Dirk
Boonen, Steven #
Issue Date: 5-Jul-2012
Publisher: Springer International
Host Document: Osteoporosis International vol:23 issue:supplement 5 pages:S556
Conference: Osteoporosis and Bone Conference location:Manchester, UK date:1-4 July 2012
Article number: P16
Abstract: Introduction: There is now considerable evidence that muscle and bone interact to impact on bone strength. The aim of this analysis was to determine the association between reduced muscle mass (sarcopenia) and areal bone mineral density (BMDa) in middle-aged and elderly community-dwelling European men.

Materials and Methods: Men aged 40-79 years from the Manchester (UK) and Leuven (Belgium) cohorts of the European Male Ageing Study (EMAS) were invited to attend for physical performance tests (time to walk 50 feet, [s]) and dual energy X-ray absorptiometry, from which appendicular lean mass (aLM, [kg]), total fat mass (FM, [kg]) and BMDa at the total hip and lumbar spine were determined. Relative appendicular skeletal muscle mass (RASM) was calculated as aLM/height² and sarcopenia defined as RASM <7.26kg/m2. Linear regression was used to determine the associations between LM, FM, physical performance and BMDa (standardized into Z-scores). Logistic regression was used to determine the association between sarcopenia and osteoporosis, defined as a T-score <-2.5 at the hip or lumbar spine.

Discussion: 679 men, mean age 60.0 (SD=11.0) were included in this analysis. Mean total hip BMDa was 1.015 (SD=0.142) g/cm² and mean lumbar spine BMDa 1.049 (SD=0.173) g/cm². 11.9% were sarcopenic and 8.8% osteoporotic. After adjustment for age and centre, increasing aLM, RASM and FM were associated with increasing BMDa at the total hip (bèta=0.139, bèta=0.433, bèta=0.049 respectively; p<0.05) and lumbar spine (bèta=0.102, bèta=0.294, bèta=0.034; p<0.05). Sarcopenic men had significantly lower BMDa at both sites compared to those with RASM ≥7.26kg/m2. In a stepwise linear regression model which included age, height, aLM, FM and physical performance, aLM was most consistently associated with BMDa (bèta=0.119 at total hip and bèta=0.101 at lumbar spine; p<0.05). Fat mass was an independent predictor at the hip (bèta=0.017; p<0.05) though not spine. After adjustment for age and centre, sarcopenic men were more likely to have osteoporosis compared to those with normal RASM (Odds Ratio=3.0; 95%CI=1.6, 5.8).

Conclusion: Sarcopenia is associated with low BMDa and osteoporosis in men. Further studies are necessary to assess whether the maintenance of muscle mass may contribute to prevent bone loss in older men.
ISSN: 0937-941X
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Gerontology and Geriatrics
Research Group for Musculoskeletal Rehabilitation
Laboratory of Molecular Endocrinology
Clinical and Experimental Endocrinology
# (joint) last author

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