Title: Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents
Authors: Rawal, Ravindra K ×
Tripathi, Rajkamal
Katti, S B
Pannecouque, Christophe
De Clercq, Erik #
Issue Date: Feb-2007
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:15 issue:4 pages:1725-31
Abstract: Compounds having isothiourea or thiourea functional group have shown high anti-HIV-1 activity. Therefore, a series of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones were designed, synthesized, and evaluated for anti-HIV-1 RT activity. The results of in vitro tests showed that the compound 9 exhibited EC(50) at 0.26muM with minimal toxicity in MT-4 cells as compared to 0.35muM for thiazobenzimidazole (TBZ). It may be inferred from the present data that majority of compounds in this series exhibit higher selectivity index than TBZ.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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