Title: Antiviral activity of HPMPC (cidofovir) against orf virus infected lambs
Authors: Scagliarini, A ×
McInnes, C J
Gallina, L
Dal Pozzo, F
Scagliarini, L
Snoeck, Robert
Prosperi, S
Sales, J
Gilray, J A
Nettleton, P F #
Issue Date: Mar-2007
Publisher: Elsevier/North-Holland
Series Title: Antiviral Research vol:73 issue:3 pages:169-174
Abstract: (S)-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPC, cidofovir, CDV, Vistide((R))) is an acyclic nucleoside analogue with a potent and selective activity against a broad spectrum of DNA viruses including the poxviruses. In this study we present the results of different treatment regimens in lambs experimentally infected with orf virus with different cidofovir formulations prepared in Beeler basis and Unguentum M. Our results show that choice of excipient, concentration of cidofovir and treatment regimen were all important to the clinical outcome of the therapy. Whilst one particular regimen appeared to exacerbate the lesion, treatment with 1% (w/v) cidofovir cream, prepared in Beeler basis, for 4 consecutive days did result in milder lesions that resolved more quickly than untreated lesions. Furthermore the scabs of the treated animals contained significantly lower amounts of viable virus meaning there should be less contamination of the environment with virus than would normally occur.
ISSN: 0166-3542
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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