Title: Human monocyte chemotactic proteins-2 and 3 (MCP-2 and MCP-3) attract human eosinophils and desensitize the chemotactic responses towards RANTES
Authors: Noso, N ×
Proost, Paul
Van Damme, Jozef
Schröder, J M #
Issue Date: May-1994
Series Title: Biochemical and Biophysical Research Communications vol:200 issue:3 pages:1470-6
Abstract: When synthetic monocyte chemotactic proteins (MCPs) were tested in a Boyden chamber assay system for eosinophil-chemotactic properties using human eosinophils, MCP-3 was found to be a potent and efficient (percentage input migrating cells) attractant with an ED50 near 2-3 nM. MCP-2 was less potent, exhibiting half maximal chemotaxis at 40 nM. Cross desensitization experiments of eosinophil-chemotaxis revealed that both MCP-3 and MCP-2 desensitized autologous responses. In addition, pretreatment of human eosinophils with natural RANTES desensitized chemotaxis towards MCP-3 as well as MCP-2, whereas pretreatment of eosinophils with MCP-3 desensitized, apart from responses to MCP-3, also responses against RANTES and MCP-2. These findings indicate that possibly both MCP-3 and MCP-2 elicit chemotactic responses via the RANTES-receptor on eosinophils.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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