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Title: 2'-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus
Authors: Goris, Nesya ×
De Palma, Armando
Toussaint, Jean-François
Musch, Ina
Neyts, Johan
De Clercq, Kris #
Issue Date: Mar-2007
Series Title: Antiviral Research vol:73 issue:3 pages:161-168
Abstract: We report on the potent and selective in vitro antiviral activity of 2'-C-methylcytidine (2'-C-MetCyt) against foot-and-mouth disease virus (FMDV). FMDV belongs to the Picornaviridae and has the potential to cause devastating epidemics in livestock. The 50% and 90% effective concentrations (EC(50) and EC(90)) for inhibition of the FMDV-induced cytopathic effect (CPE) formation were 6.4+/-3.8 and 10.8+/-5.4muM. Comparable EC(50) values for inhibition of viral RNA synthesis were observed. Treatment of FMDV-infected BHK-21 cells with 77muM 2'-C-MetCyt resulted in a (1.6-3.2)x10(3)-fold reduction of infectious virus yield. Time-of-drug addition experiments suggest that 2'-C-MetCyt interacts with viral replication at a time point that coincides with the onset of intracellular viral RNA synthesis. In contrast to emergency vaccination, a potent and selective antiviral agent may provide almost immediate (prophylactic/therapeutic) protection against infection and thus constitute an important alternative/supplementary option to contain outbreaks such as those caused by FMDV.
URI: 
ISSN: 0166-3542
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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