Title: Novel adamantylated pyrimidines and their preliminary biological evaluations
Authors: Orzeszko, Barbara ×
Kazimierczuk, Zygmunt
Maurin, Jan Krzysztof
Laudy, Agnieszka Ewa
Starościak, Bohdan Jerzy
Vilpo, Juhani
Vilpo, Leena
Balzarini, Jan
Orzeszko, Andrzej #
Issue Date: Dec-2004
Publisher: Elsevier France, Editions Scientifiques et Medicales
Series Title: Il Farmaco vol:59 issue:12 pages:929-37
Abstract: The synthesis of adamantylated pyrimidines was based on the reaction of 3-(adamantan-1-yl)-3-oxopropionic acid ethyl ester with urea, thiourea, guanidine as well as acetamidine, respectively. Then the compounds obtained were converted into respective bromo-, thio- and S-alkyl derivatives. The molecular structures for some compounds were studied by X-ray methods. The significant anticancer and antimicrobial properties of [2-(6-adamantan-1-yl-2-methylpyrimidin-4-ylthio)ethyl]dimethylamine were found.
ISSN: 0014-827X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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