Novel adamantylated pyrimidines and their preliminary biological evaluations
Orzeszko, Barbara × Kazimierczuk, Zygmunt Maurin, Jan Krzysztof Laudy, Agnieszka Ewa Starościak, Bohdan Jerzy Vilpo, Juhani Vilpo, Leena Balzarini, Jan Orzeszko, Andrzej #
Elsevier France, Editions Scientifiques et Medicales
Il Farmaco vol:59 issue:12 pages:929-37
The synthesis of adamantylated pyrimidines was based on the reaction of 3-(adamantan-1-yl)-3-oxopropionic acid ethyl ester with urea, thiourea, guanidine as well as acetamidine, respectively. Then the compounds obtained were converted into respective bromo-, thio- and S-alkyl derivatives. The molecular structures for some compounds were studied by X-ray methods. The significant anticancer and antimicrobial properties of [2-(6-adamantan-1-yl-2-methylpyrimidin-4-ylthio)ethyl]dimethylamine were found.