Title: Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine
Authors: Canoa, Pilar ×
González-Moa, María J
Teijeira, Marta
Terán, Carmen
Uriarte, Eugenio
Pannecouque, Christophe
De Clercq, Erik #
Issue Date: Oct-2006
Series Title: Chemical & pharmaceutical bulletin vol:54 issue:10 pages:1418-20
Abstract: Novel nucleoside analogues of structure 3-5 were synthesized starting from (+/-)-cis-2-amino-3-cyclopentenylmethanol (1). The chlorine derivative 3 inhibited both HIV-1 and HIV-2 replication in MT-4 cells with IC(50) values of 10.67 microM and of 13.79 microM, respectively.
ISSN: 0009-2363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science