Title: Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice
Authors: Heindryckx, Femke
Kuchnio, Anna
Casteleyn, Christophe
Coulon, Stephanie
Olievier, Kim
Colle, Isabelle
Geerts, Anja
Libbrecht, Louis
Carmeliet, Peter
Van Vlierberghe, Hans # ×
Issue Date: Jul-2012
Publisher: Elsevier Science Publishers
Series Title: Journal of Hepatology vol:57 issue:1 pages:61-68
Abstract: The two major primary liver cancers in adults are hepatocellular carcinoma and cholangiocarcinoma. These tumors rapidly outgrow their vascular supply and become hypoxic, resulting in the production of hypoxia inducible factors. Recently, interest has grown in the regulators of these factors. Several reports have been published describing the role of prolyl hydroxylase domains - the key oxygen sensor responsible for the degradation of hypoxia inducible factors - in tumor progression and vascularisation. The effect of prolyl hydroxylase domain 2 on the pathogenesis of liver cancer has never been studied.
ISSN: 0168-8278
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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