Title: Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity
Authors: Martinez, A ×
Esteban, A
Castro, A
Gil, C
Conde, S
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan
De Clercq, Erik #
Issue Date: May-2000
Series Title: Antiviral chemistry & chemotherapy vol:11 issue:3 pages:221-30
Abstract: The synthesis of acyclonucleosides derived from thieno[3,2-c] and thieno[2,3-c][1,2,6]thiadiazine 2,2-dioxides was achieved following the silylation method. Lipase-mediated methodology was employed for deprotection of the acyclic moieties. The antiviral effects were determined against a broad spectrum of viruses, including cytomegalovirus (CMV) and varicella zoster virus (VZV). Only minor antiviral activity against VZV was observed for those acyclonucleosides carrying a benzyl group.
ISSN: 0956-3202
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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