Glucose Variability and Mortality in Patients Hospitalized With Acute Myocardial Infarction
Lipska, Kasia J × Venkitachalam, Lakshmi Gosch, Kensey Kovatchev, Boris Van den Berghe, Greet Meyfroidt, Geert Jones, Philip G Inzucchi, Silvio E Spertus, John A Devries, J Hans Kosiborod, Mikhail #
Circulation. Cardiovascular quality and outcomes vol:5 issue:4 pages:550-557
BACKGROUND: <0.0001). Greater GV was associated with higher mortality for all metrics (eg, mortality was 3.8%, 5.5%, 7.1%, and 11.3% for increasing quartiles of range, P<0.0001); however, the association between GV and mortality for each metric was no longer significant after multivariable adjustment. In contrast, mean BG remained an important predictor of survival (P<0.001, all models).ConclusionsAlthough greater GV is associated with increased risk of in-hospital mortality in patients with AMI in unadjusted analyses, GV is no longer independently predictive after controlling for multiple patient factors, including mean BG. These findings suggest that GV does not provide additional prognostic value above and beyond already recognized risk factors for mortality during AMI.