Title: Insecticidal activity of the pyrimidine nucleoside analogue (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU)
Authors: Breuer, Michael ×
De Loof, Arnold
Balzarini, Jan
Huybrechts, Roger #
Issue Date: Aug-2005
Publisher: Published for SCI by Wiley
Series Title: Pest Management Science vol:61 issue:8 pages:737-741
Abstract: The insecticidal activity of the antiherpetic agent (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was assessed in in vivo assays against the fall armyworm, Spodoptera frugiperda (JE Smith) (Lepidoptera, Noctuidae). BVDU, mixed into an artificial diet, caused a variety of effects, depending on the concentration used. Compared with controls, food intake was lower, larval growth was retarded and larval development was prolonged. The treated larvae formed smaller pupae and the hatching moths often showed morphogenetic defects. A higher mortality could be found in larval and pupal stages and was generally caused by moult disruption. A choice assay showed that BVDU has very slight feeding-deterrent properties, which only partly explain the toxic effects. The agent most probably acts through its cytostatic activity that has been described previously using cell lines of different insect species.
ISSN: 1526-498X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Laboratory of Virology and Chemotherapy (Rega Institute)
Department of Biology - miscellaneous
× corresponding author
# (joint) last author

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