Title: Interaction of interferon with other cytokines
Authors: Opdenakker, Ghislain ×
Cabeza-Arvelaiz, Y
Van Damme, Jozef #
Issue Date: Jun-1989
Series Title: Experientia vol:45 issue:6 pages:513-20
Abstract: Interferons interact with other cytokines to exert their antiviral, cell growth regulatory and immunomodulatory activities. Growth factors, tumor necrosis factors, colony stimulating factors, interleukins and interferons have pleiotropic effects and form a parallel network of intercellular signals. These signals are transduced at the cell surface through specific receptors with intrinsic enzymatic activity or with the capacity to regulate intracellular enzymes through interactive effects with G-proteins. This leads to regulated gene transcription of intracellular and secreted, functional and structural proteins. Although much is known about the interaction of cytokines with their receptors and about the regulation of transcription at the genomic level the various steps linking these two phenomena deserve further research.
ISSN: 0014-4754
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Academic Center for General Practice
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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