Title: Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity
Authors: Taourirte, M ×
Mohamed, L Ait
Rochdi, A
Vasseur, J J
Fernández, S
Ferrero, M
Gotor, V
Pannecouque, Christophe
De Clercq, Erik
Lazrek, H B #
Issue Date: Jan-2004
Series Title: Nucleosides, nucleotides & nucleic acids vol:23 issue:4 pages:701-14
Abstract: Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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