Proposal for the standardisation of multi-centre trials in nuclear medicine imaging: prerequisites for a European I-123-FP-CIT SPECT database
Dickson, John Caddell × Tossici-Bolt, Livia Sera, Terez de Nijs, Robin Booij, Jan Bagnara, Maria Claudia Seese, Anita Koulibaly, Pierre Malick Akdemir, Umit Ozgur Jonsson, Cathrine Koole, Michel Raith, Maria Lonsdale, Markus Nowak George, Jean Zito, Felicia Tatsch, Klaus #
European Journal of Nuclear Medicine and Molecular Imaging vol:39 issue:1 pages:188-197
Purpose Multi-centre trials are an important part of proving the efficacy of procedures, drugs and interventions. Imaging components in such trials are becoming increasingly common; however, without sufficient control measures the usefulness of these data can be compromised. This paper describes a framework for performing high-quality multi-centre trials with single photon emission computed tomography (SPECT), using a pan-European initiative to acquire a normal control dopamine transporter brain scan database as an example.