Title: Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
Authors: Orellana-Paucar, Adriana Monserrath
Serruys, Ann-Sophie K
Afrikanova, Tatiana
Maes, Jan
De Borggraeve, Wim
Alen, Jo
León-Tamariz, Fabián
Wilches-Arizábala, Isabel María
Crawford, Alexander D
de Witte, Peter A M
Esguerra, Camila V # ×
Issue Date: May-2012
Publisher: Elsevier B.V.
Series Title: Epilepsy & Behavior vol:24 issue:1 pages:14-22
Abstract: Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the treatment of epilepsy. To date, in vivo studies on the anticonvulsant activity of turmeric have focused on its principal curcuminoid, curcumin. However, poor absorption and rapid metabolism have limited the therapeutic application of curcumin in humans. To explore the therapeutic potential of turmeric for epilepsy further, we analyzed its anticonvulsant activity in a larval zebrafish seizure assay. Initial experiments revealed that the anticonvulsant activity of turmeric in zebrafish larvae cannot be explained solely by the effects of curcumin. Zebrafish bioassay-guided fractionation of turmeric identified bisabolene sesquiterpenoids as additional anticonvulsants that inhibit PTZ-induced seizures in both zebrafish and mice. Here, we present the first report of the anticonvulsant properties of bisabolene sesquiterpenoids and provide evidence which warrants further investigation toward the mechanistic understanding of their neuromodulatory activity.
ISSN: 1525-5050
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Laboratory for Pharmaceutical Biology (-)
× corresponding author
# (joint) last author

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