Title: Galectin-1 in melanoma biology and related neo-angiogenesis processes
Authors: Mathieu, Véronique ×
de Lassalle, Elisabeth Martin
Toelen, Jaan
Mohr, Thomas
Bellahcène, Akeila
Van Goietsenoven, Gwendoline
Verschuere, Tina
Bouzin, Caroline
Debyser, Zeger
De Vleeschouwer, Steven
Van Gool, Stefaan
Poirier, Françoise
Castronovo, Vincent
Kiss, Robert
Feron, Olivier #
Issue Date: Sep-2012
Publisher: Elsevier Science Pub. Co.
Series Title: Journal of Investigative Dermatology vol:132 issue:9 pages:2245-2254
Article number: 10.1038/jid.2012.142
Abstract: Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles, galectin (gal)-1 expressed and/or secreted by both cancer and endothelial cells stimulates proliferation and angiogenesis. This study first shows that gal-1 is more highly expressed at both mRNA and protein levels than its congeners in melanomas and particularly in advanced lesions. The roles of gal-1 were further investigated in vivo in the highly proliferating and vascularized pseudometastatic B16F10 mouse melanoma model using stable knockdown B16F10 cells and wild-type versus gal-1 knockout mice, and then in vitro in B16F10 tumoral and lung microvascular cells. Gal-1 depletion in the B16F10 tumor cells but not in the tumor-bearing mice significantly increased melanoma-bearing mice survival. Tumor-derived gal-1 thus seems to have more critical roles than the host-derived one. In fact, gal-1 displays distinct effects on the H-Ras-dependent p53/p21 pathways: in primary lung microvessel endothelial cells, gal-1 seems to be involved in the maintenance of senescent status through the induction of both p53 and p21 while it stimulates B16F10 cancer cell proliferation through a p53/p21 decrease. Altogether, these data point to gal-1 as a potential target to combat melanomas.Journal of Investigative Dermatology advance online publication, 24 May 2012; doi:10.1038/jid.2012.142.
ISSN: 0022-202X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
Laboratory of Pediatric Immunology
Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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