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Title: Improvement of Clostridium tumour targeting vectors evaluated in rat rhabdomyosarcomas
Authors: Theys, Jan ×
Landuyt, W
Nuyts, Sandra
Van Mellaert, Lieve
Bosmans, E
Rijnders, A
Van den Bogaert, Walter
Van Oosterom, Allan
Anné, Jozef
Lambin, Philippe #
Issue Date: Feb-2001
Series Title: FEMS Immunology and Medical Microbiology vol:30 issue:1 pages:37-41
Abstract: Previous studies have demonstrated the feasibility of using apathogenic clostridia as a promising strategy for hypoxia-specific tumour targeting. The present study shows that the use of the vascular targeting compound combretastatin A-4 phosphate could significantly (P<0.001) increase the number of Clostridium vegetative cells in rat rhabdomyosarcomas with sizes between 0.2 cm(2) and 3 cm(2). Furthermore, this study showed that administration of metronidazole for a 9-day period was sufficient to eliminate systemically administered Clostridium from the tumour. Moreover, previous Clostridium spore administration did not effect tumour colonisation, regardless of the immune response status of the host.
ISSN: 0928-8244
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Oncology - miscellaneous
Laboratory of Molecular Bacteriology (Rega Institute)
Laboratory of Experimental Radiotherapy
× corresponding author
# (joint) last author

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