Upregulation of transient receptor potential vanilloid type-1 receptor expression in oral lichen planus
Bán, Agnes × Marincsák, Rita Bíró, Tamás Perkecz, Anikó Gömöri, Eva Sándor, Katalin Tóth, Balázs István Bánvölgyi, Agnes Szolcsányi, János Pintér, Erika #
S. Karger Medical and Scientific Publishers
Neuroimmunomodulation vol:17 issue:2 pages:103-8
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa. Its etiology is still unclear. Neurogenic components might contribute to the inflammatory process. The oral mucosa is richly innervated by sensory fibers. Mediators secreted by inflammatory cells activate sensory nerves via transient receptor potential vanilloid receptor 1 (TRPV1) and lead to the release of neuropeptides. So far, TRPV1 receptor expression was detected on neurons. Only recently, TRPV1 receptors were identified in nonneuronal tissues. The aim of the present study was to detect the presence of TRPV1 receptors and peripheral expression of receptor mRNA in normal oral mucosa and mucous membranes from OLP patients.